There has long been a reluctance, born out of experience, that making data from experiments on animals (particularly nonhuman primates) publicly available is inadvisable because of the potential for information to be taken out of context by those who oppose animal research. We have argued vigorously that the public health emergency of Zika virus demands transparent, open data sharing. We ask that those of you who consider using information we provide here to slow research on Zika virus to reconsider. We know nearly nothing about the virology, immunology, and pathogenesis of this virus. Zika virus infection of pregnant women has been associated with severe birth defects, but it is still far from clear how, or how often, Zika virus infection may induce these defects in developing fetuses. There have also been anecdotal reports that Zika virus can be transmitted sexually, and that it is shed in saliva. With the minimal data available, we cannot yet determine how severe the risks of sexual or other non-mosquito transmission of Zika might be. Understanding these critical biological features in animals where we control the dose, route, and timing of infection will accelerate the accumulation of knowledge and hopefully alleviate the suffering of people who are impacted by this virus. Some may not agree that this is sufficient justification for animal research; we can respectfully disagree.